Unlock unparalleled growth potential with pioneering investments in the third wave of drug reform.
Ride the Wave: Inside the exciting world of Third Wave drug reform investing - discover news, deals, and policy shifts shaping the future.
We provide:
The latest news
Market insights
Unique insights
Investment opportunities
Market Opportunity
The Third Wave of drug reform creates a 700+ billion opportunity for investors.
| Sector | Market Size Estimate in USD | |
|---|---|---|
| Medical Cannabis | 22B in 2023¹ | 97B by 2033¹ |
| Recreational Cannabis | 24B in 2023² | 49B by 2028² |
| Illicit Drugs | 652B in 2022⁶ | - |
| Ketamine | 9B in 2022³ | 26B by 2030⁴ |
| Psilocybin | 1.1B in 2022⁵ | 3.2B by 2030⁷ |
| LSD | 380M in 2022⁵ | - |
| MDMA | 80M in 2022⁵ | 136B USD⁹ |
| DMT | 300M in 2022⁵ | - |
| TOTAL: | ||
3 Waves of Drug Reform
First Wave
Decriminalization of Marijuana
This wave focused on reducing legal penalties and eventually legalizing the use of marijuana, often initially for medicinal purposes and later for recreational use, reflecting a shift in public perception about its relative harm and potential benefits.
2013-2018
Approximately $100 billion of value created and early investors generated 1,000s of % returns.
Second Wave
Decriminalization of Psychedelics
This phase involved the gradual reduction of legal restrictions on psychedelics like psilocybin and LSD, often driven by emerging research suggesting therapeutic benefits for mental health conditions and a re-evaluation of their societal and cultural impacts.
2019-2022
Approximately $20 billion of value created and early investors generated 1,000s of % returns on invested capital.
Third Wave
Decriminalization of Other Drugs
The most recent wave represents a broader shift towards decriminalizing a range of previously illegal substances, influenced by arguments for harm reduction, the failures of the war on drugs, and a growing emphasis on treating drug use as a public health issue rather than a criminal one.
2023-Present
Early investors stand to profit significantly from decriminalization efforts worldwide.
Industry News
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Who Is To Blame For The Growing Fentanyl Problem?
The United States is grappling with a relentless surge in fentanyl-related overdose deaths, marking a grim chapter in the ongoing battle against opioid addiction. As the fourth wave of the opioid epidemic crashes through communities nationwide, the devastating toll of fentanyl misuse has left families shattered and communities reeling.
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![Cocaine Plays? Meet the Companies With an Angle on Hard Drugs]()
Cocaine Plays? Meet the Companies With an Angle on Hard Drugs
If “what are you smoking?” used to the be the skeptical response to those who said marijuana would one day be legal in more than 38 US states, the new catchphrase might be “what are you snorting?”
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![We’re on the cusp of another psychedelic era. But this time Washington is along for the ride]()
We’re on the cusp of another psychedelic era. But this time Washington is along for the ride
There’s a new cause in Washington that’s uniting Republicans, Democrats and Biden health officials: psychedelics as a cure for America’s mental health crisis.
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Why More States are Decriminalizing Fentanyl Test Strips
More red states are moving to decriminalize test strips used to detect fentanyl in illicit or counterfeit drugs as the substance becomes a leading killer of adults under 50.
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Canada To Legalise Cocaine, Decriminalisation-Supporting Startups Across Nation Predict
Canada is looking at legalising cocaine and startups are popping up across the country hoping to cash in on a future where hard drugs are decriminalized, much like cannabis and psychedelics.
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![‘Shrooms go upscale amid psychedelics craze]()
‘Shrooms go upscale amid psychedelics craze
Millions of affluent Americans are using hallucinogens to self-medicate for psychological problems, producing America’s newest illegal drug boom.
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![Safe Supply's Vision Includes Bet on Legal Cocaine]()
Safe Supply's Vision Includes Bet on Legal Cocaine
Safe Supply Streaming Co. (CSE: SPLY), a startup, has entered the Canadian Securities Exchange with an intriguing focus on the potential legalization of cocaine. The company anticipates a third wave of policy changes that could decriminalize hard drugs, following the path of cannabis and psychedelics.
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‘For God’s sake, do something’: Richard Branson urges NSW to act on drug reform
Sir Richard Branson has added his voice to calls for the New South Wales government to enact serious drug reform and announce a timeframe for its promised drug summit, pleading with the state to decriminalise drugs.
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Lives at risk unless NSW introduces drug testing before festival season, health groups warn
Further lives are at risk if the New South Wales government does not begin a drug testing trial for the summer festival season, according to a coalition of peak health bodies and the independent MP Alex Greenwich.
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Swiss city considers legalizing cocaine for recreational use in pilot program: ‘War on drugs has failed’
The capital of Switzerland is considering launching a pilot program to test the legal sale of cocaine for recreational use in a never-before-done attempt to make the country’s rampant use of the drug safer.
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Australia will allow prescription MDMA and magic mushrooms for some people with mental illness
Australian regulators announced in February that psychiatrists will be able to prescribe psilocybin and MDMA as medication for certain mental health conditions starting July 1 of this year.
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Psychedelic Drugs Are Rushing Towards Approval for Therapy. Here’s What’s Next
Psychedelics made their mark this year—not as counterculture party drugs, but as a new paradigm in mental health therapy.
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‘The law needs to be changed’: Nelson group rallies in support of safe drug supply
A small group of people braved minus-10 weather on Tuesday to stand outside Nelson City Hall in solidarity with the founders of the Drug User Liberation Front who appeared in court the same day in Vancouver.
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Harm reduction advocates in Calgary renew calls for safe supply to prevent drug poisoning deaths
The provincial government pulled funding for the site after a financial audit found evidence of mismanagement and misuse of government funding by the non-profit group that ran it, ARCHES. A smaller mobile overdose prevention site, run by AHS, remains outside the Lethbridge Stabilization Centre and Shelter.
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Legal cocaine stock applauds Amsterdam mayor’s call for new narcotics regulation
Safe Supply Streaming (CSE:SPLY), a stock investing in legal cocaine, applauds a recent statement from Amsterdam mayor Femke Halsema. Halsema called for the new regulation of the sale and use of narcotics, primarily cocaine, to counteract the economics of illegal enterprises “racking up billions in profit.”
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Calls for more 'safer opioid' access in Nova Scotia as drug supply increasingly toxic
As the illicit drugs that have devastated Western and Central Canada become more prevalent in Nova Scotia, a Halifax physician is renewing calls to expand access to "safer opioid supply" treatment to prevent overdoses and deaths.
We have highlighted 3 front-runners in the sector for you to learn more about which are featured in our industry report:
Opportunities
Led by pioneers in the cannabis and psychedelics industries, Safe Supply is the first venture capital firm investing in the burgeoning safe supply ecosystem, the third wave of drug reform and an end to the war on drugs.
Harbour is disrupting and growing multi-billion-dollar industries in pharma, food & beverage, nutraceuticals, and sustainable agricultural fertilizer as the only Canadian coca leaf importer and processor.
Safety Strips is your trusted partner in ensuring drug safety. They are dedicated to combating the growing opioid crisis by providing a reliable solution for detecting fentanyl in your supply.
Watch Now
Safe Supply Ecosystem
The streaming model will allow Safe Supply Streaming to capitalize on deals across the value chain and being first to market gives us strong foundation to capitalize the balance sheet.
Investing Across the Value Chain
Safe Supply Streaming uses stream financing to scale high-integrity narcotics, wellness, healthcare & biotechnology businesses to support Health Canada and the Provincial Government in creating a $5+ billion legal narcotics / safe supply industry in British Columbia.
Regulations
Canada
In 2023, Health Canada granted an exemption under the Controlled Drugs and Substances Act to the Province of B.C. This is effective from January 31, 2023 to January 31, 2026. Under this exemption, adults (18 years and older) in B.C. are not arrested or charged for possessing small amounts of certain illegal drugs for personal use. The illegal drugs covered by the exemption include opioids (such as heroin, morphine, and fentanyl), crack and powder cocaine, methamphetamine (Meth), MDMA (Ecstasy).
Portugal
In 2001, Portugal decriminalized the personal possession of all drugs as part of a wider re-orientation of policy towards a health-led approach. Possessing drugs for personal use is instead treated as an administrative offence, meaning it is no longer punishable by imprisonment and does not result in a criminal record and associated stigma.1 Drugs are, however, still confiscated and possession may result in administrative penalties such as fines or community service.
Australia
From July 1, 2023, medicines containing the psychedelic substances psilocybin and MDMA (3,4-methylenedioxy-methamphetamine) can be prescribed by specifically authorised psychiatrists for the treatment of certain mental health conditions. The Therapeutic Goods Administration (TGA) will permit the prescribing of MDMA for the treatment of post-traumatic stress disorder and psilocybin for treatment-resistant depression.
Switzerland
Switzerland's capital city, Bern, has signalled its intent to conduct a scientific pilot trial of controlled cocaine sales. With 43 votes to 18, the city parliament approved a motion from the Alternative Left to extend trials with cannabis to the future legal sale of cocaine. Despite recognising that cocaine is a harmful drug, Bern politicians believe that supervised sales could lead to better control of the narcotic.
United States
On January 4, 2023, several changes related to the passing of Colorado Proposition 122 went into effect that could impact the Centennial State’s economy, law enforcement and its healthcare system as it relates to alternative therapies for treating mental health conditions. adults ages 21 and over no longer face criminal penalties under Colorado state or local laws for possession or personal use of “natural medicine” found in psychedelic (magic) mushrooms, including: psilocybin, psilocin, dimethyltryptamine (DMT), and ibogaine.
Download “The Third Wave Opportunity of Drug Reform” Industry Report
This report focuses on the evolving landscape of drug reform, specifically highlighting the third wave of the opioid crisis. It delves into the significant investment opportunities emerging from this wave, driven by changes in drug laws and public perception around substances like cannabis, psychedelics, and opioids.
“The third wave of drug reform presents a groundbreaking opportunity for forward-thinking investors to invest in companies at the forefront of this transformation.”
— Bill Panagiotakopoulos, CEO, Safe Supply